KPV - KEGG Pathway Viewer

Term	Meaning
Metabolic pathway	In biochemistry, a metabolic pathway is a linked series of chemical reactions occurring within a cell. The term network is sometimes defined to mean a graph in which attributes (e.g. names) are associated with the vertices and edges, and the subject that expresses and understands the real-world systems as a network is called network science.
Network/Graphs	In mathematics, graph theory is the study of graphs, which are mathematical structures used to model pairwise relations between objects.
Network visualization	Graph visualization is a way of representing structural information as diagrams of abstract graphs and networks. It has important applications in networking, bioinformatics, software engineering, database and web design, machine learning, and in visual interfaces for other technical domains.
Node	In mathematics, and more specifically in graph theory, a vertex (plural vertices) or node is the fundamental unit of which graphs are formed.
Edge	For an undirected graph, an unordered pair of nodes that specify a line joining these two nodes are said to form an edge. For a directed graph, the edge is an ordered pair of nodes. The terms "arc," "branch," "line," "link," and "1-simplex" are sometimes used instead of edge.
KEGG	KEGG: Kyoto Encyclopedia of Genes and Genomes is a Japanese database resource for understanding high-level functions and utilities of the biological system, such as the cell, the organism and the ecosystem, from molecular-level information, especially large-scale molecular datasets generated by genome sequencing and other high-throughput experimental technologies.
KEGG Pathway	KEGG PATHWAY is a collection of manually drawn pathway maps representing the knowledge on the molecular interaction, reaction and relation.
Pathway code	Each pathway map is identified by the combination of 2-4 letter prefix code and 5 digit number.
Articulation point	In a graph, a vertex is called an articulation point if removing it and all the edges associated with it results in the increase of the number of connected components in the graph.
Articulation point impact	The impact is defined as the number of vertices that get disconnected from the main (largest) surviving connected component after the removal of the articulation point node.
AP node	AP is the abbreviation for Articulation point.
HAP node	AP is the abbreviation for Hub and Articulation point.
HUB node	In network science, a hub is a node with a number of links that greatly exceeds the average.
Other nodes	In the context of this tool, other nodes represent nodes without classification.

00909 Sesquiterpenoid and triterpenoid biosynthesis
Metabolism; Metabolism of terpenoids and polyketides

Sesquiterpenoids (C15 terpenoids) are a group of terpenoids consisting of three isoprene units. They are derive from farnesyl diphosphate (FPP) and can be cyclized to produce various skeletal structures. Sesquiterpenoid biosynthesis begins with the loss of diphosphate from FPP under the action of sesquiterpene synthesis enzymes, generating an allylic cation that is highly susceptible to intramolecular attacks. Cyclization of the farnesyl cation may take place onto either of the remaining double bonds with the result that 6-, 10-, or 11-membered rings may be formed. Many sesquiterpenoids have been isolated from plants, fungi, marine organisms, and Streptomyces species. This map shows a few examples of acyclic and cyclic sesquiterpenoids.

Nodes	Edges
51	42

Articulation point with highest impact	Disconnected nodes when remove it
ec:1.14.14.17	6

Global metrics
12	1.6471	0.0006

Nodes classification
7	3	10	44

Total organisms
988

Eukaryotes	Prokaryotes
226	762

Animals	Plants	Fungi	Protists	Bacteria	Archaea
0	105	121	0	699	63

list(REFERENCE = "PMID:9371761", AUTHORS = "Crock J, Wildung M, Croteau R", TITLE = "Isolation and bacterial expression of a sesquiterpene synthase cDNA clone from peppermint (Mentha x piperita, L.) that produces the aphid alarm pheromone (E)-beta-farnesene.", JOURNAL = c("Proc Natl Acad Sci U S A 94:12833-8 (1997)", "DOI:10.1073/pnas.94.24.12833")), list(REFERENCE = "PMID:18363779", AUTHORS = "Nagegowda DA, Gutensohn M, Wilkerson CG, Dudareva N", TITLE = "Two nearly identical terpene synthases catalyze the formation of nerolidol and linalool in snapdragon flowers.", JOURNAL = c("Plant J 55:224-39 (2008)", "DOI:10.1111/j.1365-313X.2008.03496.x")), list(REFERENCE = "PMID:16579958", AUTHORS = "Bertea CM, Voster A, Verstappen FW, Maffei M, Beekwilder J, Bouwmeester HJ", TITLE = "Isoprenoid biosynthesis in Artemisia annua: cloning and heterologous expression of a germacrene A synthase from a glandular trichome cDNA library.", JOURNAL = c("Arch Biochem Biophys 448:3-12 (2006)", "DOI:10.1016/j.abb.2006.02.026")), list(REFERENCE = "PMID:12011356", AUTHORS = "de Kraker JW, Franssen MC, Joerink M, de Groot A, Bouwmeester HJ", TITLE = "Biosynthesis of costunolide, dihydrocostunolide, and leucodin. Demonstration of cytochrome p450-catalyzed formation of the lactone ring present in sesquiterpene lactones of chicory.", JOURNAL = c("Plant Physiol 129:257-68 (2002)", "DOI:10.1104/pp.010957")), list(REFERENCE = "PMID:17226502", AUTHORS = "Jaroszewski JW, Strom-Hansen T, Hansen SH, Thastrup O, Kofod H", TITLE = "On the botanical distribution of chiral forms of gossypol.", JOURNAL = c("Planta Med 58:454-8 (1992)", "DOI:10.1055/s-2006-961512")), list(REFERENCE = "PMID:9442047", AUTHORS = "Steele CL, Crock J, Bohlmann J, Croteau R", TITLE = "Sesquiterpene synthases from grand fir (Abies grandis). Comparison of constitutive and wound-induced activities, and cDNA isolation, characterization, and bacterial expression of delta-selinene synthase and gamma-humulene synthase.", JOURNAL = c("J Biol Chem 273:2078-89 (1998)", "DOI:10.1074/jbc.273.4.2078")), list(REFERENCE = "PMID:19030608", AUTHORS = "Fraga BM", TITLE = "Natural sesquiterpenoids.", JOURNAL = c("Nat Prod Rep 25:1180-209 (2008)", "DOI:10.1039/b806216c")), list(REFERENCE = "PMID:21876149", AUTHORS = "Field B, Fiston-Lavier AS, Kemen A, Geisler K, Quesneville H, Osbourn AE", TITLE = "Formation of plant metabolic gene clusters within dynamic chromosomal regions.", JOURNAL = c("Proc Natl Acad Sci U S A 108:16116-21 (2011)", "DOI:10.1073/pnas.1109273108")), list(REFERENCE = "PMID:18356490", AUTHORS = "Field B, Osbourn AE", TITLE = "Metabolic diversification--independent assembly of operon-like gene clusters in different plants.", JOURNAL = c("Science 320:543-7 (2008)", "DOI:10.1126/science.1154990")), list(REFERENCE = "PMID:15148404", AUTHORS = "Qi X, Bakht S, Leggett M, Maxwell C, Melton R, Osbourn A", TITLE = "A gene cluster for secondary metabolism in oat: implications for the evolution of metabolic diversity in plants.", JOURNAL = c("Proc Natl Acad Sci U S A 101:8233-8 (2004)", "DOI:10.1073/pnas.0401301101"))

KPV - KEGG Pathway Viewer
by Igor Brandão

Loading..

00909 Sesquiterpenoid and triterpenoid biosynthesis
Metabolism; Metabolism of terpenoids and polyketides

51
NODES

42
EDGES

988
ORGANISMS

12
COMMUNITIES

1.6471
AVG. DEGREE

0.0006
AVG. BETWEENNESS

7
ARTICULATION POINTS

44
OTHER NODES

Filters

Pathway Viewer

51

42

ec:1.14.14.17

6

12

1.6471

0.0006

7

3

10

44

988

226

762

0

105

121

0

699

63

Global metrics
Communities	Avg. degree	Avg. betweenness
12	1.6471	0.0006

KPV - KEGG Pathway Viewer by Igor Brandão

Loading..

00909 Sesquiterpenoid and triterpenoid biosynthesis Metabolism; Metabolism of terpenoids and polyketides

51 NODES

42 EDGES

988 ORGANISMS

12 COMMUNITIES

1.6471 AVG. DEGREE

0.0006 AVG. BETWEENNESS

7 ARTICULATION POINTS

44 OTHER NODES