KPV - KEGG Pathway Viewer
by Igor Brandão

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In the table below, you'll find the most used terms in this tool:

Term	Meaning
Metabolic pathway	In biochemistry, a metabolic pathway is a linked series of chemical reactions occurring within a cell. The term network is sometimes defined to mean a graph in which attributes (e.g. names) are associated with the vertices and edges, and the subject that expresses and understands the real-world systems as a network is called network science.
Network/Graphs	In mathematics, graph theory is the study of graphs, which are mathematical structures used to model pairwise relations between objects.
Network visualization	Graph visualization is a way of representing structural information as diagrams of abstract graphs and networks. It has important applications in networking, bioinformatics, software engineering, database and web design, machine learning, and in visual interfaces for other technical domains.
Node	In mathematics, and more specifically in graph theory, a vertex (plural vertices) or node is the fundamental unit of which graphs are formed.
Edge	For an undirected graph, an unordered pair of nodes that specify a line joining these two nodes are said to form an edge. For a directed graph, the edge is an ordered pair of nodes. The terms "arc," "branch," "line," "link," and "1-simplex" are sometimes used instead of edge.
KEGG	KEGG: Kyoto Encyclopedia of Genes and Genomes is a Japanese database resource for understanding high-level functions and utilities of the biological system, such as the cell, the organism and the ecosystem, from molecular-level information, especially large-scale molecular datasets generated by genome sequencing and other high-throughput experimental technologies.
KEGG Pathway	KEGG PATHWAY is a collection of manually drawn pathway maps representing the knowledge on the molecular interaction, reaction and relation.
Pathway code	Each pathway map is identified by the combination of 2-4 letter prefix code and 5 digit number.
Articulation point	In a graph, a vertex is called an articulation point if removing it and all the edges associated with it results in the increase of the number of connected components in the graph.
Articulation point impact	The impact is defined as the number of vertices that get disconnected from the main (largest) surviving connected component after the removal of the articulation point node.
AP node	AP is the abbreviation for Articulation point.
HAP node	AP is the abbreviation for Hub and Articulation point.
HUB node	In network science, a hub is a node with a number of links that greatly exceeds the average.
Other nodes	In the context of this tool, other nodes represent nodes without classification.

Pathways List
Use the list below to find informations about KEGG metabolic pathways. Click on the pathway name to access the network visualization.

Pathways

137 Pathways found

PATHWAY	NODES	EDGES	ORGANISMS	COMMUNITIES	AVG. DEGREE	AVG. BETWEENNESS	ARTICULATION POINTS
00010 - Glycolysis / Gluconeogenesis Metabolism; Carbohydrate metabolism Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate [PATH:map00010], Glycolysis, core module i Glycolysis is the process of converting glucose into pyruvate and generating small amounts of ATP (energy) and NADH (reducing power). It is a central pathway that produces important precursor metabolites: six-carbon compounds of glucose-6P and fructose-6P and three-carbon compounds of glycerone-P, glyceraldehyde-3P, glycerate-3P, phosphoenolpyruvate, and pyruvate [MD:M00001]. Acetyl-CoA, another important precursor metabolite, is produced by oxidative decarboxylation of pyruvate [MD:M00307]. Whe... Present in: 531 eukaryotes / 5566 prokaryotes	40	132	6097	4	6.5000	0.1082	3
00020 - Citrate cycle (TCA cycle) Metabolism; Carbohydrate metabolism Gluconeogenesis, oxaloacetate => fructose-6P [PATH:map00020], Citrate cycle (TCA cycle, Krebs cycle) The citrate cycle (TCA cycle, Krebs cycle) is an important aerobic pathway for the final steps of the oxidation of carbohydrates and fatty acids. The cycle starts with acetyl-CoA, the activated form of acetate, derived from glycolysis and pyruvate oxidation for carbohydrates and from beta oxidation of fatty acids. The two-carbon acetyl group in acetyl-CoA is transferred to the four-carbon compound of oxaloacetate to form the six-carbon compound of citrate. In a series of reactions two carbons in... Present in: 526 eukaryotes / 5490 prokaryotes	24	88	6016	4	7.1667	0.0800	0
00030 - Pentose phosphate pathway Metabolism; Carbohydrate metabolism Pentose phosphate pathway (Pentose phosphate cycle) [PATH:map00030], PRPP biosynthesis, ribose 5P => The pentose phosphate pathway is a process of glucose turnover that produces NADPH as reducing equivalents and pentoses as essential parts of nucleotides. There are two different phases in the pathway. One is irreversible oxidative phase in which glucose-6P is converted to ribulose-5P by oxidative decarboxylation, and NADPH is generated [MD:M00006]. The other is reversible non-oxidative phase in which phosphorylated sugars are interconverted to generate xylulose-5P, ribulose-5P, and ribose-5P [M... Present in: 531 eukaryotes / 5533 prokaryotes	46	167	6064	8	7.1739	0.0361	8
00040 - Pentose and glucuronate interconversions Metabolism; Carbohydrate metabolism Glucuronate pathway (uronate pathway) [PATH:map00040], D-Glucuronate degradation, D-glucuronate => p ... Present in: 525 eukaryotes / 5015 prokaryotes	65	199	5540	11	6.1231	0.0502	13
00051 - Fructose and mannose metabolism Metabolism; Carbohydrate metabolism Ascorbate biosynthesis, plants, glucose-6P => ascorbate [PATH:map00051] ... Present in: 531 eukaryotes / 5515 prokaryotes	64	182	6046	11	5.6250	0.0224	13
00052 - Galactose metabolism Metabolism; Carbohydrate metabolism Non-phosphorylative Entner-Doudoroff pathway, gluconate/galactonate => glycerate [PATH:map00052], D- ... Present in: 526 eukaryotes / 5207 prokaryotes	46	184	5733	5	6.1739	0.0383	2
00053 - Ascorbate and aldarate metabolism Metabolism; Carbohydrate metabolism Ascorbate biosynthesis, plants, glucose-6P => ascorbate [PATH:map00053], Ascorbate biosynthesis, ani ... Present in: 493 eukaryotes / 3802 prokaryotes	46	111	4295	6	4.7391	0.0272	19
00061 - Fatty acid biosynthesis Metabolism; Lipid metabolism Fatty acid biosynthesis, initiation [PATH:map00061], Fatty acid biosynthesis, elongation [PATH:map00 ... Present in: 416 eukaryotes / 5346 prokaryotes	57	126	5762	13	3.2982	0.0835	16
00062 - Fatty acid elongation Metabolism; Lipid metabolism Fatty acid elongation in mitochondria [PATH:map00062], Fatty acid elongation in endoplasmic reticulu ... Present in: 522 eukaryotes / 1 prokaryotes	34	88	523	9	3.4118	0.0538	1
00071 - Fatty acid degradation Metabolism; Lipid metabolism beta-Oxidation, acyl-CoA synthesis [PATH:map00071], beta-Oxidation [PATH:map00071] ... Present in: 529 eukaryotes / 4655 prokaryotes	44	115	5184	12	4.2273	0.0386	14
00072 - Synthesis and degradation of ketone bodies Metabolism; Lipid metabolism Ketone body biosynthesis, acetyl-CoA => acetoacetate/3-hydroxybutyrate/acetone [PATH:map00072] ... Present in: 492 eukaryotes / 3310 prokaryotes	6	14	3802	2	4.6667	0.1000	0
00073 - Cutin, suberine and wax biosynthesis Metabolism; Lipid metabolism ... Present in: 102 eukaryotes / 1 prokaryotes	8	6	103	3	1.5000	0.0060	2
00100 - Steroid biosynthesis Metabolism; Lipid metabolism Cholesterol biosynthesis, squalene 2,3-epoxide => cholesterol [PATH:map00100], Ergocalciferol biosyn ... Present in: 502 eukaryotes / 583 prokaryotes	52	61	1085	8	2.3462	0.0240	41
00120 - Primary bile acid biosynthesis Metabolism; Lipid metabolism Bile acid biosynthesis, cholesterol => cholate/chenodeoxycholate [PATH:map00120], Conjugated bile ac Bile acids are steroid carboxylic acids derived from cholesterol in vertebrates. The primary bile acids, cholic acid and chenodeoxycholic acid, are synthesized in the liver and conjugated with taurine or glycine before secretion via bile into the intestine. The conversion from cholesterol to cholic and chenodeoxycholic acids involves four steps: 1) the initiation of synthesis by 7alpha-hydroxylation of sterol precursors, 2) further modifications to the ring structures, 3) side-chain oxidation an... Present in: 145 eukaryotes / 0 prokaryotes	47	71	145	8	2.4444	0.0045	20
00130 - Ubiquinone and other terpenoid-quinone biosynthesis Metabolism; Metabolism of cofactors and vitamins Tocopherol/tocotorienol biosynthesis [PATH:map00130], Menaquinone biosynthesis, chorismate => menaqu Ubiquinone (UQ), also called coenzyme Q, and plastoquinone (PQ) are electron carriers in oxidative phosphorylation and photosynthesis, respectively. The quinoid nucleus of ubiquinone is derived from the shikimate pathway; 4-hydroxybenzoate is directly formed from chorismate in bacteria, while it can be formed from either chorismate or tyrosine in yeast. The following biosynthesis of terpenoid moiety involves reactions of prenylation, decarboxylation, and three hydroxylations alternating with thr... Present in: 495 eukaryotes / 4719 prokaryotes	44	49	5214	8	2.2273	0.0062	30
00140 - Steroid hormone biosynthesis Metabolism; Lipid metabolism Steroid hormone biosynthesis, cholesterol => prognenolone => progesterone [PATH:map00140], C21-Stero Steroid hormones derived from cholesterol are a class of biologically active compounds in vertebrates. The cholesterol side-chain cleavage enzyme CYP11A1 catalyzes conversion of cholesterol, a C27 compound, to the first C21 steroid, pregnenolone, which is converted by a bifunctional enzyme complex to the gestagen hormone, progesterone [MD:M00107]. Pregnenolone and progesterone are the starting materials for the three groups of steroids: C21 steroids of glucocorticoids and mineralocorticoids, C19... Present in: 145 eukaryotes / 0 prokaryotes	107	184	145	17	3.3962	0.0045	32
00220 - Arginine biosynthesis Metabolism; Amino acid metabolism Ornithine biosynthesis, glutamate => ornithine [PATH:map00220], Urea cycle [PATH:map00220], Ornithin ... Present in: 524 eukaryotes / 5304 prokaryotes	21	53	5828	3	5.0476	0.0591	0
00230 - Purine metabolism Metabolism; Nucleotide metabolism PRPP biosynthesis, ribose 5P => PRPP [PATH:map00230], Inosine monophosphate biosynthesis, PRPP + glu ... Present in: 531 eukaryotes / 5552 prokaryotes	115	370	6083	15	6.4000	0.0256	10
00232 - Caffeine metabolism Metabolism; Biosynthesis of other secondary metabolites UMBBD: caf caf2 ... Present in: 163 eukaryotes / 3 prokaryotes	23	34	166	6	2.9565	0.0255	7
00240 - Pyrimidine metabolism Metabolism; Nucleotide metabolism Pyrimidine degradation, uracil => beta-alanine, thymine => 3-aminoisobutanoate [PATH:map00240], Urid ... Present in: 531 eukaryotes / 5552 prokaryotes	89	286	6083	12	6.4045	0.0272	21
00250 - Alanine, aspartate and glutamate metabolism Metabolism; Amino acid metabolism GABA (gamma-Aminobutyrate) shunt [PATH:map00250], Methylaspartate cycle [PATH:map00250] ... Present in: 526 eukaryotes / 5453 prokaryotes	40	143	5979	4	7.1500	0.0368	6
00253 - Tetracycline biosynthesis Metabolism; Metabolism of terpenoids and polyketides Type II polyketide backbone biosynthesis, acyl-CoA + malonyl-CoA => polyketide [PATH:map00253], Tetr Tetracyclines are aromatic polyketide antibiotics produced by Streptomyces species via type II polyketide synthases (PKSs). Tetracyclines contain a linear tetracyclic skeleton, which is formed from a malonamate starter unit and malonyl-CoA extender units through a common polyketide pathway [MD:M00778]. This diagram shows biosynthesis of naturally occurring tetracyclines (tetracycline, oxytetracycline and chlortetracycline) via a common intermediate anhydrotetracycline [MD:M00780 M00823].... Present in: 0 eukaryotes / 74 prokaryotes	11	9	74	4	1.6364	0.0232	5
00254 - Aflatoxin biosynthesis Metabolism; Biosynthesis of other secondary metabolites ... Present in: 10 eukaryotes / 0 prokaryotes	20	19	10	5	1.9000	0.0083	7
00260 - Glycine, serine and threonine metabolism Metabolism; Amino acid metabolism Threonine biosynthesis, aspartate => homoserine => threonine [PATH:map00260], Serine biosynthesis, g Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].... Present in: 530 eukaryotes / 5556 prokaryotes	55	220	6086	11	8.0000	0.0271	8
00261 - Monobactam biosynthesis Metabolism; Biosynthesis of other secondary metabolites Nocardicin A biosynthesis, L-pHPG + arginine + serine => nocardicin A [PATH:map00261] Monobactams are beta-lactam antibiotics containing a monocyclic beta-lactam nucleus, which is structurally different from penicillin and cephalosporin core structures with another fused ring. This diagram shows biosynthesis of nocardicin A, a naturally occurring monobactam, via the pentapeptide formed by condensation of L-4-hydroxyphenylglycine (L-pHPG), L-arginine and L-serine [MD:M00736]. Other naturally occurring monobactams are also shown but the biosynthetic pathway is not yet fully charact... Present in: 241 eukaryotes / 5224 prokaryotes	9	6	5465	4	1.3333	0.0060	0
00270 - Cysteine and methionine metabolism Metabolism; Amino acid metabolism Methionine biosynthesis, apartate => homoserine => methionine [PATH:map00270], Cysteine biosynthesis Cysteine and methionine are sulfur-containing amino acids. Cysteine is synthesized from serine through different pathways in different organism groups. In bacteria and plants, cysteine is converted from serine (via acetylserine) by transfer of hydrogen sulfide [MD:M00021]. In animals, methionine-derived homocysteine is used as sulfur source and its condensation product with serine (cystathionine) is converted to cysteine [MD:M00338]. Cysteine is metabolized to pyruvate in multiple routes. Methio... Present in: 527 eukaryotes / 5557 prokaryotes	79	222	6084	9	5.6203	0.0308	15
00280 - Valine, leucine and isoleucine degradation Metabolism; Amino acid metabolism Leucine degradation, leucine => acetoacetate + acetyl-CoA [PATH:map00280], Propanoyl-CoA metabolism, ... Present in: 530 eukaryotes / 5512 prokaryotes	42	96	6042	7	3.8095	0.0321	5
00281 - Geraniol degradation Metabolism; Metabolism of terpenoids and polyketides UMBBD: ger cit ... Present in: 0 eukaryotes / 3045 prokaryotes	9	6	3045	3	1.3333	0.0099	4
00290 - Valine, leucine and isoleucine biosynthesis Metabolism; Amino acid metabolism Valine/isoleucine biosynthesis, pyruvate => valine / 2-oxobutanoate => isoleucine [PATH:map00290], L ... Present in: 504 eukaryotes / 5214 prokaryotes	20	26	5718	6	2.6000	0.0285	15
00300 - Lysine biosynthesis Metabolism; Amino acid metabolism Lysine biosynthesis, succinyl-DAP pathway, aspartate => lysine [PATH:map00300], Lysine biosynthesis, ... Present in: 259 eukaryotes / 5399 prokaryotes	29	47	5658	6	3.1724	0.0194	15
00310 - Lysine degradation Metabolism; Amino acid metabolism Lysine degradation, lysine => saccharopine => acetoacetyl-CoA [PATH:map00310] ... Present in: 528 eukaryotes / 4850 prokaryotes	52	97	5378	9	3.7647	0.0142	8
00311 - Penicillin and cephalosporin biosynthesis Metabolism; Biosynthesis of other secondary metabolites Penicillin biosynthesis, aminoadipate + cycteine + valine => penicillin [PATH:map00311], Cephamycin Penicillins (Penams) and cephalosporins (cephems) are beta-lactam antibiotics containing 6-aminopenicillanate (6-APA) and 7-aminocephalosporanate (7-ACA) nuclei, respectively. 6-APA and 7-ACA are key intermediates for a variety of semisynthetic penicillin and cephalosporin derivatives. Penicillins are produced only by fungi, while cephalosporins (including cephamycins) are produced by fungi and bacteria. Both antibiotics are synthesized from L-2-aminoadipate, L-cysteine and L-valine through a co... Present in: 7 eukaryotes / 685 prokaryotes	12	13	692	3	2.1667	0.0523	8
00330 - Arginine and proline metabolism Metabolism; Amino acid metabolism Proline biosynthesis, glutamate => proline [PATH:map00330], Creatine pathway [PATH:map00330], Polyam ... Present in: 523 eukaryotes / 5313 prokaryotes	85	217	5836	11	5.0588	0.0097	19
00331 - Clavulanic acid biosynthesis Metabolism; Biosynthesis of other secondary metabolites Clavaminate biosynthesis, arginine + glyceraldehyde-3P => clavaminate [PATH:map00331] ... Present in: 0 eukaryotes / 7 prokaryotes	6	5	7	3	1.6667	0.1667	4
00332 - Carbapenem biosynthesis Metabolism; Biosynthesis of other secondary metabolites Carbapenem-3-carboxylate biosynthesis, pyrroline-5-carboxylate + malonyl-CoA => carbapenem-3-carboxy Carbapenems are broad-spectrum beta-lactam antibiotics, which are often considered as the antibiotics of last resort. A naturally occurring carbapenem, thienamycin, was first discovered in Streptomyces cattleya. This diagram shows how a simple carbapenem, carbapenem-3-carboxylate, is synthesized from malonyl-CoA and pyrroline-5-carboxylate [MD:M00675]. For structurally complex carbapenems, such as thienamycin, olivanic acid, epi-thienamycin and carbapenems of the OA-6129 group, uncertainty remai... Present in: 130 eukaryotes / 4180 prokaryotes	5	3	4310	2	1.2000	0.0167	1
00333 - Prodigiosin biosynthesis Metabolism; Biosynthesis of other secondary metabolites Prodigiosin biosynthesis, L-proline => prodigiosin [PATH:map00333], Undecylprodigiosin biosynthesis, Prodiginines are red-pigmented natural antibiotics that are produced as secondary metabolites and have received renewed attention because of potential clinical interests. In Serratia sp. or actinomycetes such as Streptomyces coelicolor, the tripyrrole molecules of prodigiosin and undecylprodigiosin are formed by the condensation of 4-methoxy-2,2`-bipyrrole-5-carbaldehyde and either 2-methyl-3-n-amyl-pyrrole [MD:M00837] or 2-undecylpyrrole [MD:M00838]. The Serratia pig gene cluster and the Strept... Present in: 0 eukaryotes / 21 prokaryotes	2	1	21	2	1.0000	1.0000	0
00340 - Histidine metabolism Metabolism; Amino acid metabolism Histidine biosynthesis, PRPP => histidine [PATH:map00340], Histidine degradation, histidine => N-for ... Present in: 494 eukaryotes / 4669 prokaryotes	39	56	5163	8	2.7692	0.0412	21
00350 - Tyrosine metabolism Metabolism; Amino acid metabolism Catecholamine biosynthesis, tyrosine => dopamine => noradrenaline => adrenaline [PATH:map00350], Thy ... Present in: 509 eukaryotes / 4821 prokaryotes	72	156	5330	12	4.3333	0.0039	20
00360 - Phenylalanine metabolism Metabolism; Amino acid metabolism Trans-cinnamate degradation, trans-cinnamate => acetyl-CoA [PATH:map00360], Phenylacetate degradatio ... Present in: 504 eukaryotes / 4810 prokaryotes	54	108	5314	13	4.0000	0.0136	16
00361 - Chlorocyclohexane and chlorobenzene degradation Metabolism; Xenobiotics biodegradation and metabolism Benzene/toluene degradation, benzene => catechol / toluene => 3-methylcatechol [PATH:map00361], Benz ... Present in: 0 eukaryotes / 2738 prokaryotes	43	28	2738	15	1.3171	0.0003	13
00362 - Benzoate degradation Metabolism; Xenobiotics biodegradation and metabolism Benzoate degradation, cyclohexanecarboxylic acid =>pimeloyl-CoA [PATH:map00362], Benzoyl-CoA degrada ... Present in: 0 eukaryotes / 4320 prokaryotes	67	103	4320	13	3.0746	0.0125	20
00363 - Bisphenol degradation Metabolism; Xenobiotics biodegradation and metabolism UMBBD: tbp2 bpa hap bpf ... Present in: 0 eukaryotes / 2 prokaryotes	2	1	2	2	1.0000	1.0000	0
00364 - Fluorobenzoate degradation Metabolism; Xenobiotics biodegradation and metabolism UMBBD: 3fb 4fb box dcb ... Present in: 0 eukaryotes / 2270 prokaryotes	17	13	2270	5	1.5294	0.0071	11
00365 - Furfural degradation Metabolism; Xenobiotics biodegradation and metabolism ... Present in: 0 eukaryotes / 92 prokaryotes	2	1	92	2	1.0000	1.0000	0
00380 - Tryptophan metabolism Metabolism; Amino acid metabolism Melatonin biosynthesis, tryptophan => serotonin => melatonin [PATH:map00380], Tryptophan metabolism, ... Present in: 521 eukaryotes / 4192 prokaryotes	62	62	4713	9	2.0000	0.0009	39
00400 - Phenylalanine, tyrosine and tryptophan biosynthesis Metabolism; Amino acid metabolism Shikimate pathway, phosphoenolpyruvate + erythrose-4P => chorismate [PATH:map00400], Tryptophan bios ... Present in: 526 eukaryotes / 5328 prokaryotes	35	76	5854	6	4.3429	0.0707	13
00401 - Novobiocin biosynthesis Metabolism; Biosynthesis of other secondary metabolites D02333, Coumermycin (USAN) ... Present in: 0 eukaryotes / 4680 prokaryotes	12	11	4680	4	1.8333	0.0848	7
00402 - Benzoxazinoid biosynthesis Metabolism; Biosynthesis of other secondary metabolites Benzoxazinoids (hydroxamic acids) are plant secondary metabolites that serve as important factors for host resistance against microbial pathogens and insects and for allelopathic effects. They are found in grass family and some eudicot families. The predominant benzoxazinoids are DIBOA and its 7-methoxy derivative DIMBOA, which are stored as glucosides in vacuoles. In maize, benzoxazinoid biosynthesis branches off from tryptophan biosynthesis at indole-3-glycerol phosphate, which is converted to... Present in: 4 eukaryotes / 0 prokaryotes	8	7	4	3	1.7500	0.1667	8
00404 - Staurosporine biosynthesis Metabolism; Biosynthesis of other secondary metabolites Fumitremorgin alkaloid biosynthesis, tryptophan + proline => fumitremorgin C/A [PATH:map00404], Rebe ... Present in: 3 eukaryotes / 62 prokaryotes	17	14	65	4	1.6471	0.0189	13
00405 - Phenazine biosynthesis Metabolism; Biosynthesis of other secondary metabolites Pyocyanine biosynthesis, chorismate => pyocyanine [PATH:map00405] ... Present in: 0 eukaryotes / 645 prokaryotes	18	13	645	6	1.4444	0.0123	8
00410 - beta-Alanine metabolism Metabolism; Metabolism of other amino acids Malonate semialdehyde pathway, propanoyl-CoA => acetyl-CoA [PATH:map00410] ... Present in: 507 eukaryotes / 4455 prokaryotes	33	125	4962	8	7.3333	0.0157	11
00430 - Taurine and hypotaurine metabolism Metabolism; Metabolism of other amino acids Phosphate acetyltransferase-acetate kinase pathway, acetyl-CoA => acetate [PATH:map00430] ... Present in: 498 eukaryotes / 4853 prokaryotes	18	33	5351	4	3.6667	0.0313	10
00440 - Phosphonate and phosphinate metabolism Metabolism; Metabolism of other amino acids Spondylometaphyseal dysplasia with cone-rod dystrophy Natural products containing carbon-phosphorous bonds, so-called C-P compounds, are derivatives of phosphonate and phosphinate with substitution of alkyl group for hydrogen of phosphorus-hydrogen bonds. C-P compounds have been found in many organisms, but only protists and bacteria, mostly Actinobacteria, have biosynthetic capacity. A common reaction in the biosynthetic pathway is C-P bond forming reaction from phosphoenolpyruvate (PEP) to phosphonopyruvate (PnPy) catalyzed by PEP phosphomutase. ... Present in: 491 eukaryotes / 1935 prokaryotes	29	27	2426	10	1.8621	0.0078	18
00450 - Selenocompound metabolism Metabolism; Metabolism of other amino acids Homocystinuria, Hypermethioninemia, SEMD, Pakistani type, Methylcobalamin deficiency type G ... Present in: 513 eukaryotes / 5300 prokaryotes	8	8	5813	3	2.0000	0.0298	3
00460 - Cyanoamino acid metabolism Metabolism; Metabolism of other amino acids Cyanogenic glycoside biosynthesis, tyrosine => dhurrin [PATH:map00460] ... Present in: 262 eukaryotes / 4865 prokaryotes	40	48	5127	9	2.3158	0.0099	25
00471 - D-Glutamine and D-glutamate metabolism Metabolism; Metabolism of other amino acids Familial hyperinsulinemic hypoglycemia ... Present in: 247 eukaryotes / 5348 prokaryotes	13	22	5595	3	3.3846	0.0163	5
00472 - D-Arginine and D-ornithine metabolism Metabolism; Metabolism of other amino acids ... Present in: 0 eukaryotes / 373 prokaryotes	11	30	373	2	5.4545	0.0586	3
00473 - D-Alanine metabolism Metabolism; Metabolism of other amino acids ... Present in: 0 eukaryotes / 4768 prokaryotes	5	8	4768	5	3.2000	0.0000	0
00480 - Glutathione metabolism Metabolism; Metabolism of other amino acids Glutathione biosynthesis, glutamate => glutathione [PATH:map00480] ... Present in: 531 eukaryotes / 5478 prokaryotes	38	142	6009	12	7.5556	0.0463	6
00500 - Starch and sucrose metabolism Metabolism; Carbohydrate metabolism Trehalose biosynthesis, D-glucose 1P => trehalose [PATH:map00500], Glycogen biosynthesis, glucose-1P ... Present in: 531 eukaryotes / 5308 prokaryotes	74	328	5839	5	8.8649	0.0371	1
00520 - Amino sugar and nucleotide sugar metabolism Metabolism; Carbohydrate metabolism Nucleotide sugar biosynthesis, glucose => UDP-glucose [PATH:map00520], Nucleotide sugar biosynthesis ... Present in: 531 eukaryotes / 5510 prokaryotes	116	275	6041	17	4.7069	0.0207	51
00521 - Streptomycin biosynthesis Metabolism; Biosynthesis of other secondary metabolites dTDP-L-rhamnose biosynthesis [PATH:map00521] Streptomycin is an aminocyclitol-aminoglycoside antibiotic produced by Streptomyces griseus. Streptomycin consists of aminocyclitol (streptidine), 6-deoxyhexose (streptose), and N-methyl-L-glucosamine moieties, which are formed by independent biosynthetic pathways. All of the moieties are derived from D-glucose. The streptidine moiety is synthesized via myo-inositol, which is then oxidized at C-1 and transaminated to give scyllo-inosamine. After phosphorylation, the compound is transamidinated b... Present in: 0 eukaryotes / 5066 prokaryotes	15	15	5066	5	2.0000	0.0355	12
00523 - Polyketide sugar unit biosynthesis Metabolism; Metabolism of terpenoids and polyketides dTDP-L-rhamnose biosynthesis [PATH:map00523], dTDP-6-deoxy-D-allose biosynthesis [PATH:map00523], dT ... Present in: 4 eukaryotes / 3953 prokaryotes	26	26	3957	6	2.0000	0.0065	19
00524 - Neomycin, kanamycin and gentamicin biosynthesis Metabolism; Biosynthesis of other secondary metabolites D00063, Tobramycin (JP17/USP), D02322, Apramycin (USAN/INN), D05140, Framycetin (INN), D07467, Parom ... Present in: 149 eukaryotes / 31 prokaryotes	35	41	180	6	2.0000	0.0237	30
00525 - Acarbose and validamycin biosynthesis Metabolism; Biosynthesis of other secondary metabolites Acarbose biosynthesis, sedoheptulopyranose-7P => acarbose [PATH:map00525], Validamycin A biosynthesi ... Present in: 0 eukaryotes / 3756 prokaryotes	14	10	3756	4	1.4286	0.0055	8
00550 - Peptidoglycan biosynthesis Metabolism; Glycan biosynthesis and metabolism Peptidoglycan is a macromolecule made of long aminosugar strands cross-linked by short peptides. It forms the cell wall in bacteria surrounding the cytoplasmic membrane. The glycan strands are typically comprised of repeating N-acetylglucosamine (GlcNAc) and N-acetylmuramic acid (MurNAc) disaccharides. Each MurNAc is linked to a peptide of three to five amino acid residues. Disaccharide subunits are first assembled on the cytoplasmic side of the bacterial membrane on a polyisoprenoid anchor (lip... Present in: 0 eukaryotes / 5049 prokaryotes	20	22	5049	5	2.2000	0.0531	11
00561 - Glycerolipid metabolism Metabolism; Lipid metabolism Triacylglycerol biosynthesis [PATH:map00561], Acylglycerol degradation [PATH:map00561] ... Present in: 531 eukaryotes / 5274 prokaryotes	41	89	5805	8	4.3415	0.0289	10
00562 - Inositol phosphate metabolism Metabolism; Carbohydrate metabolism Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4 [PATH:map00562], Inositol ... Present in: 531 eukaryotes / 4782 prokaryotes	54	109	5313	8	4.0370	0.0502	14
00564 - Glycerophospholipid metabolism Metabolism; Lipid metabolism Phosphatidylcholine (PC) biosynthesis, choline => PC [PATH:map00564], Phosphatidylcholine (PC) biosy ... Present in: 531 eukaryotes / 5512 prokaryotes	68	154	6043	9	4.5294	0.0548	9
00565 - Ether lipid metabolism Metabolism; Lipid metabolism Sulfoglycolipids biosynthesis, ceramide/1-alkyl-2-acylglycerol => sulfatide/seminolipid [PATH:map005 ... Present in: 507 eukaryotes / 429 prokaryotes	25	37	936	5	2.9600	0.0123	15
00590 - Arachidonic acid metabolism Metabolism; Lipid metabolism Diaphyseal dysplasia with anemia, Leukotriene C4 synthase deficiency ... Present in: 517 eukaryotes / 3165 prokaryotes	38	38	3682	6	2.0000	0.0015	23
00591 - Linoleic acid metabolism Metabolism; Lipid metabolism ... Present in: 341 eukaryotes / 206 prokaryotes	13	12	547	2	1.8462	0.0012	4
00592 - alpha-Linolenic acid metabolism Metabolism; Lipid metabolism Jasmonic acid biosynthesis [PATH:map00592] ... Present in: 384 eukaryotes / 348 prokaryotes	13	9	732	5	1.3846	0.0064	6
00600 - Sphingolipid metabolism Metabolism; Lipid metabolism Lactosylceramide biosynthesis [PATH:map00600], Sulfoglycolipids biosynthesis, ceramide/1-alkyl-2-acy ... Present in: 515 eukaryotes / 2025 prokaryotes	36	96	2540	6	5.3333	0.0287	6
00620 - Pyruvate metabolism Metabolism; Carbohydrate metabolism CAM (Crassulacean acid metabolism), dark [PATH:map00620], CAM (Crassulacean acid metabolism), light ... Present in: 531 eukaryotes / 5570 prokaryotes	59	519	6101	3	17.5254	0.0258	1
00621 - Dioxin degradation Metabolism; Xenobiotics biodegradation and metabolism Biphenyl degradation, biphenyl => 2-oxopent-4-enoate + benzoate [PATH:map00621], Carbazole degradati Dioxins and dioxin-like compounds, including PCDDs, PCDFs and PCBs, are persistent organic pollutants (POPs) that are resistant to environmental degradation. However, POPs can be degraded by certain microorganisms with acquisition of a novel set of enzymes, such as biphenyl degradation by Paraburkholderia xenovorans LB400 involving four novel enzymes encoded in operon-like structures [MD:M00543]. DDT, another POP, and carbazol are also known to be degraded in similar pathways.... Present in: 0 eukaryotes / 1104 prokaryotes	14	12	1104	4	1.7143	0.0096	9
00622 - Xylene degradation Metabolism; Xenobiotics biodegradation and metabolism Cymene degradation, p-cymene => p-cumate [PATH:map00622], Xylene degradation, xylene => methylbenzoa ... Present in: 0 eukaryotes / 2119 prokaryotes	27	22	2119	7	1.6296	0.0043	14
00623 - Toluene degradation Metabolism; Xenobiotics biodegradation and metabolism Toluene degradation, anaerobic, toluene => benzoyl-CoA [PATH:map00623], Toluene degradation, toluene ... Present in: 0 eukaryotes / 941 prokaryotes	32	21	941	11	1.2667	0.0004	11
00624 - Polycyclic aromatic hydrocarbon degradation Metabolism; Xenobiotics biodegradation and metabolism Phthalate degradation, phthalate => protocatechuate [PATH:map00624], Terephthalate degradation, tere ... Present in: 0 eukaryotes / 782 prokaryotes	23	22	782	6	1.9130	0.0098	13
00625 - Chloroalkane and chloroalkene degradation Metabolism; Xenobiotics biodegradation and metabolism ... Present in: 0 eukaryotes / 2870 prokaryotes	23	16	2870	7	1.3913	0.0008	9
00626 - Naphthalene degradation Metabolism; Xenobiotics biodegradation and metabolism Naphthalene degradation, naphthalene => salicylate [PATH:map00626], Salicylate degradation, salicyla ... Present in: 0 eukaryotes / 723 prokaryotes	12	9	723	4	1.5000	0.0379	6
00627 - Aminobenzoate degradation Metabolism; Xenobiotics biodegradation and metabolism Anthranilate degradation, anthranilate => catechol [PATH:map00627] ... Present in: 0 eukaryotes / 3843 prokaryotes	45	44	3843	10	1.9556	0.0016	14
00630 - Glyoxylate and dicarboxylate metabolism Metabolism; Carbohydrate metabolism Glyoxylate cycle [PATH:map00630], Ethylmalonyl pathway [PATH:map00630], Photorespiration [PATH:map00 ... Present in: 530 eukaryotes / 5507 prokaryotes	69	278	6037	15	8.0580	0.0305	6
00633 - Nitrotoluene degradation Metabolism; Xenobiotics biodegradation and metabolism ... Present in: 0 eukaryotes / 744 prokaryotes	4	2	744	2	1.0000	0.0000	0
00640 - Propanoate metabolism Metabolism; Carbohydrate metabolism Malonate semialdehyde pathway, propanoyl-CoA => acetyl-CoA [PATH:map00640], Propanoyl-CoA metabolism ... Present in: 530 eukaryotes / 5533 prokaryotes	55	249	6063	9	9.0545	0.0359	11
00642 - Ethylbenzene degradation Metabolism; Xenobiotics biodegradation and metabolism ... Present in: 0 eukaryotes / 151 prokaryotes	4	3	151	4	1.5000	0.0833	1
00643 - Styrene degradation Metabolism; Xenobiotics biodegradation and metabolism ... Present in: 0 eukaryotes / 2904 prokaryotes	21	21	2904	5	2.0000	0.0056	11
00650 - Butanoate metabolism Metabolism; Carbohydrate metabolism GABA (gamma-Aminobutyrate) shunt [PATH:map00650] ... Present in: 507 eukaryotes / 5348 prokaryotes	46	150	5855	7	6.5217	0.0439	6
00660 - C5-Branched dibasic acid metabolism Metabolism; Carbohydrate metabolism Isoleucine biosynthesis, pyruvate => 2-oxobutanoate [PATH:map00660] ... Present in: 228 eukaryotes / 4733 prokaryotes	23	35	4961	6	3.0435	0.0284	11
00670 - One carbon pool by folate Metabolism; Metabolism of cofactors and vitamins Tetrahydrofolate biosynthesis, GTP => THF [PATH:map00670], C1-unit interconversion, prokaryotes [PAT ... Present in: 526 eukaryotes / 5512 prokaryotes	28	241	6038	2	17.0714	0.0405	0
00710 - Carbon fixation in photosynthetic organisms Metabolism; Energy metabolism Reductive pentose phosphate cycle (Calvin cycle) [PATH:map00710], Reductive pentose phosphate cycle, ... Present in: 108 eukaryotes / 433 prokaryotes	23	60	541	5	5.0435	0.0427	0
00720 - Carbon fixation pathways in prokaryotes Metabolism; Energy metabolism Reductive citrate cycle (Arnon-Buchanan cycle) [PATH:map00720], Dicarboxylate-hydroxybutyrate cycle Carbon fixation is an important pathway for autotrophs living in various environments. Plants and cyanobacteria fix CO2 as organic compounds using solar energy mainly by the reductive pentose phosphate cycle (also called Calvin cycle, Calvin-Benson cycle, or Calvin-Benson-Bassham cycle) [MD:M00165]. There are, at least, five additional carbon fixation pathways known to exist in autotrophic bacteria and archaea, which differ in reducing compounds, energy source, and oxygen sensitivity of enzymes.... Present in: 0 eukaryotes / 350 prokaryotes	47	137	350	7	5.8298	0.0491	11
00730 - Thiamine metabolism Metabolism; Metabolism of cofactors and vitamins Thiamine biosynthesis, AIR => thiamine-P/thiamine-2P [PATH:map00730] ... Present in: 530 eukaryotes / 5525 prokaryotes	26	38	6055	6	2.9231	0.0687	9
00740 - Riboflavin metabolism Metabolism; Metabolism of cofactors and vitamins Riboflavin biosynthesis, GTP => riboflavin/FMN/FAD [PATH:map00740] ... Present in: 514 eukaryotes / 5411 prokaryotes	19	26	5925	4	2.7368	0.0702	10
00750 - Vitamin B6 metabolism Metabolism; Metabolism of cofactors and vitamins Pyridoxal biosynthesis, erythrose-4P => pyridoxal-5P [PATH:map00750] ... Present in: 500 eukaryotes / 4844 prokaryotes	31	62	5344	7	4.0000	0.0293	11
00760 - Nicotinate and nicotinamide metabolism Metabolism; Metabolism of cofactors and vitamins NAD biosynthesis, aspartate => NAD [PATH:map00760], Nicotinate degradation, nicotinate => fumarate [ ... Present in: 524 eukaryotes / 5505 prokaryotes	54	122	6029	10	4.5185	0.0124	23
00770 - Pantothenate and CoA biosynthesis Metabolism; Metabolism of cofactors and vitamins Valine/isoleucine biosynthesis, pyruvate => valine / 2-oxobutanoate => isoleucine [PATH:map00770], P ... Present in: 525 eukaryotes / 5494 prokaryotes	28	48	6019	5	3.4286	0.0504	10
00780 - Biotin metabolism Metabolism; Metabolism of cofactors and vitamins Biotin biosynthesis, pimeloyl-ACP/CoA => biotin [PATH:map00780], Pimeloyl-ACP biosynthesis, BioC-Bio Biotin (vitamin H or vitamin B7) is the essential cofactor of biotin-dependent carboxylases, such as pyruvate carboxylase and acetyl-CoA carboxylase. Mammals cannot synthesize biotin, while in bacteria, fungi, and plants it is synthesized from pimelate thioester through different pathways. In E. coli and many organisms, pimelate thioester is derived from malonyl-ACP. The pathway starts with the methylation to malonyl-ACP methyl ester, followed by the fatty acid chain elongation cycle to form pim... Present in: 517 eukaryotes / 5343 prokaryotes	21	22	5860	5	1.9048	0.0904	18
00785 - Lipoic acid metabolism Metabolism; Metabolism of cofactors and vitamins ... Present in: 506 eukaryotes / 4246 prokaryotes	9	7	4752	3	1.5556	0.0020	4
00790 - Folate biosynthesis Metabolism; Metabolism of cofactors and vitamins Tetrahydrofolate biosynthesis, GTP => THF [PATH:map00790], Tetrahydrofolate biosynthesis, mediated b ... Present in: 525 eukaryotes / 5446 prokaryotes	59	89	5971	12	2.9655	0.0048	23
00791 - Atrazine degradation Metabolism; Xenobiotics biodegradation and metabolism UMBBD: atr cya cnm cpm, GO: 0019381 ... Present in: 100 eukaryotes / 816 prokaryotes	9	8	916	3	1.7778	0.0238	7
00830 - Retinol metabolism Metabolism; Metabolism of cofactors and vitamins Retinitis pigmentosa, Familial flecked retina syndrome, Leber congenital amaurosis, Hypercarotenemia ... Present in: 243 eukaryotes / 0 prokaryotes	13	14	243	3	2.1538	0.0175	7
00860 - Porphyrin and chlorophyll metabolism Metabolism; Metabolism of cofactors and vitamins Heme biosynthesis, plants and bacteria, glutamate => heme [PATH:map00860], Cobalamin biosynthesis, c ... Present in: 526 eukaryotes / 5083 prokaryotes	115	162	5609	20	2.8000	0.0056	44
00900 - Terpenoid backbone biosynthesis Metabolism; Metabolism of terpenoids and polyketides C5 isoprenoid biosynthesis, mevalonate pathway [PATH:map00900], C5 isoprenoid biosynthesis, non-meva Terpenoids, also known as isoprenoids, are a large class of natural products consisting of isoprene (C5) units. There are two biosynthetic pathways, the mevalonate pathway [MD:M00095] and the non-mevalonate pathway or the MEP/DOXP pathway [MD:M00096], for the terpenoid building blocks: isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). The action of prenyltransferases then generates higher-order building blocks: geranyl diphosphate (GPP), farsenyl diphosphate (FPP), and geranyl... Present in: 531 eukaryotes / 5419 prokaryotes	49	89	5950	8	3.6327	0.0200	17
00901 - Indole alkaloid biosynthesis Metabolism; Biosynthesis of other secondary metabolites ... Present in: 25 eukaryotes / 0 prokaryotes	33	27	25	8	1.6364	0.0027	19
00902 - Monoterpenoid biosynthesis Metabolism; Metabolism of terpenoids and polyketides Monoterpenoids (C10 terpenoids) are a group of terpenoids consisting of two isoprene units. They are derived from geranyl diphosphate (GPP). Most monoterpenoids are volatile oils with highly distinctive aromas and flavors, such as essential oils, turpentine, and oleoresins of coniferous plants. This map shows some examples. The monoterpene ketone l-menthone is specifically converted to l-menthol and d-neomenthol in mature peppermint leaves. The iridoids constitute a family of highly oxygenated m... Present in: 61 eukaryotes / 0 prokaryotes	47	42	61	10	1.7021	0.0012	31
00903 - Limonene and pinene degradation Metabolism; Metabolism of terpenoids and polyketides ... Present in: 0 eukaryotes / 165 prokaryotes	34	27	165	7	1.5758	0.0011	19
00904 - Diterpenoid biosynthesis Metabolism; Metabolism of terpenoids and polyketides ... Present in: 95 eukaryotes / 0 prokaryotes	89	88	95	13	1.9277	0.0007	56
00905 - Brassinosteroid biosynthesis Metabolism; Metabolism of terpenoids and polyketides Castasterone biosynthesis, campesterol => castasterone [PATH:map00905] Brassinosteroids are a group of plant steroid hormones that regulate growth and development. More than fifty naturally occurring brassinosteroids have been identified in a wide range of plant species. The most abundant and widely occurring brassinosteroids are C28 steroids, and among them brassinolide (BL) is the most biologically active. Plants have multiple pathways for biosynthesis of BL, which are derived from the steroid biosynthetic pathway. Two pathways from campestanol to castasterone (C... Present in: 91 eukaryotes / 0 prokaryotes	2	1	91	2	1.0000	-1.0000	0
00906 - Carotenoid biosynthesis Metabolism; Metabolism of terpenoids and polyketides beta-Carotene biosynthesis, GGAP => beta-carotene [PATH:map00906], Abscisic acid biosynthesis, beta- ... Present in: 162 eukaryotes / 2155 prokaryotes	89	105	2317	11	2.2727	0.0018	55
00908 - Zeatin biosynthesis Metabolism; Metabolism of terpenoids and polyketides Zeatin is a member of the cytokinin family, a class of phytohormones involved in various processes of growth and development in plants. Most abundant cytokinins are adenine-type, where the N6 position of adenine is substituted with an isoprenoid, such as in zeatin, or an aromatic side chain, such as in kinetin. Zeatin can be synthesized in two different pathways: the tRNA pathway and the AMP pathway. In the tRNA pathway zeatin is a recycled product of isopentenylated tRNAs. In the AMP pathway ze... Present in: 91 eukaryotes / 0 prokaryotes	4	3	91	4	1.5000	0.0000	2
00909 - Sesquiterpenoid and triterpenoid biosynthesis Metabolism; Metabolism of terpenoids and polyketides Sesquiterpenoids (C15 terpenoids) are a group of terpenoids consisting of three isoprene units. They are derive from farnesyl diphosphate (FPP) and can be cyclized to produce various skeletal structures. Sesquiterpenoid biosynthesis begins with the loss of diphosphate from FPP under the action of sesquiterpene synthesis enzymes, generating an allylic cation that is highly susceptible to intramolecular attacks. Cyclization of the farnesyl cation may take place onto either of the remaining double ... Present in: 226 eukaryotes / 762 prokaryotes	51	42	988	12	1.6471	0.0006	10
00910 - Nitrogen metabolism Metabolism; Energy metabolism Nitrogen fixation, nitrogen => ammonia [PATH:map00910], Nitrification, ammonia => nitrite [PATH:map0 The biological process of the nitrogen cycle is a complex interplay among many microorganisms catalyzing different reactions, where nitrogen is found in various oxidation states ranging from +5 in nitrate to -3 in ammonia. The core nitrogen cycle involves four reduction pathways and two oxidation pathways. Nitrogen fixation [MD:M00175] is the process of reducing atmospheric molecular nitrogen to ammonia, a biologically useful reduced form incorporated into amino acids and other vital compounds. ... Present in: 519 eukaryotes / 5116 prokaryotes	4	9	5635	4	4.5000	0.1250	0
00920 - Sulfur metabolism Metabolism; Energy metabolism Cysteine biosynthesis, serine => cysteine [PATH:map00920], Assimilatory sulfate reduction, sulfate = Sulfur is an essential element for life and the metabolism of organic sulfur compounds plays an important role in the global sulfur cycle. Sulfur occurs in various oxidation states ranging from +6 in sulfate to -2 in sulfide (H2S). Sulfate reduction can occur in both an energy consuming assimilatory pathway and an energy producing dissimilatory pathway. The assimilatory pathway, which is found in a wide range of organisms, produces reduced sulfur compounds for the biosynthesis of S-containing am... Present in: 505 eukaryotes / 5100 prokaryotes	28	60	5605	5	4.2857	0.0128	9
00930 - Caprolactam degradation Metabolism; Xenobiotics biodegradation and metabolism ... Present in: 0 eukaryotes / 2099 prokaryotes	19	23	2099	5	2.2105	0.0084	12
00940 - Phenylpropanoid biosynthesis Metabolism; Biosynthesis of other secondary metabolites Monolignol biosynthesis, phenylalanine/tyrosine => monolignol [PATH:map00940], Flavanone biosynthesi Phenylpropanoids are a group of plant secondary metabolites derived from phenylalanine and having a wide variety of functions both as structural and signaling molecules. Phenylalanine is first converted to cinnamic acid by deamination. It is followed by hydroxylation and frequent methylation to generate coumaric acid and other acids with a phenylpropane (C6-C3) unit. Reduction of the CoA-activated carboxyl groups of these acids results in the corresponding aldehydes and alcohols. The alcohols ar... Present in: 97 eukaryotes / 0 prokaryotes	64	85	97	11	2.6563	0.0043	16
00941 - Flavonoid biosynthesis Metabolism; Biosynthesis of other secondary metabolites Flavanone biosynthesis, phenylalanine => naringenin [PATH:map00941], Flavonoid biosynthesis, naringe Flavonoids are a major class of plant secondary metabolites that serves a multitude of functions including pigments and antioxidant activity. Flavonoids are synthesized from phenylpropanoid derivatives by condensation with malonyl-CoA. For example, condensation of p-coumaroyl-CoA (C6-C3) with three malonyl-CoA (C3) molecules results in naringenin chalcone with a diphenylpropane (C6-C3-C6) unit, which is converted to naringenin with the flavone (2-phenylchromen-4-one) backbone by conjugate ring c... Present in: 92 eukaryotes / 0 prokaryotes	76	86	92	10	2.2632	0.0016	42
00942 - Anthocyanin biosynthesis Metabolism; Biosynthesis of other secondary metabolites Anthocyanidins (aglycones) and anthocyanins (glycosides) are common plant pigments and belong to a structural subclass of flavonoids characterized by a 2-phenylbenzopyrylium unit. They are derived along the flavonoid modification pathways and further separated into three types, pelargonidin, cyanidin, and delphinidin, due to the different number of hydroxyl groups in the phenyl group.... Present in: 73 eukaryotes / 0 prokaryotes	32	29	73	6	1.8125	0.0008	22
00943 - Isoflavonoid biosynthesis Metabolism; Biosynthesis of other secondary metabolites Isoflavonoids are biologically active compounds, such as phytoestrogens, produced by pea family plants. While flavonoids (in the narrow sense) have the 2-phenylchromen-4-one backbone, isoflavonoids have the 3-phenylchromen-4-one backbone with no hydroxyl group substitution at position 2. Isoflavonoids are derived from the flavonoid biosynthesis pathway via liquiritigenin or naringenin.... Present in: 42 eukaryotes / 0 prokaryotes	46	44	42	8	1.9130	0.0027	24
00944 - Flavone and flavonol biosynthesis Metabolism; Biosynthesis of other secondary metabolites Flavones and flavonols (3-hydroxyflavones) are common flavonoids in the plant kingdom. They are synthesized as part of the flavonoid modification pathways in aglycone and glucoside forms.... Present in: 88 eukaryotes / 0 prokaryotes	36	33	88	6	1.8333	0.0010	27
00945 - Stilbenoid, diarylheptanoid and gingerol biosynthesis Metabolism; Biosynthesis of other secondary metabolites Stilbenoids are a group of phenolic compounds, biosynthetically interrelated through their common origin from a C6-C2-C6 intermediate, such as resveratol found in grapes. Stilbenoids can also exist as glycosides (e.g., piceid). Combretastatins are potentially useful stilbenoid natural products with known antitumor activity. Diarylheptanoid is a compound group having phenyl rings at 1,7 positions of n-heptane (C6-C7-C6), such as curcumin found in the ginger family. [6]-Gingerol is a major active ... Present in: 91 eukaryotes / 0 prokaryotes	17	16	91	5	1.8824	0.0147	12
00950 - Isoquinoline alkaloid biosynthesis Metabolism; Biosynthesis of other secondary metabolites Isoquinoline alkaloids are tyrosine-derived plant alkaloids with an isoquinoline skeleton. Among them benzylisoquinoline alkaloids form an important group with potent pharmacological activity, including analgesic compounds of morphine and codeine, and anti-infective agents of berberine, palmatine, and magnoflorine. Biosynthesis of isoquinoline alkaloids proceeds via decarboxylation of tyrosine or DOPA to yield dopamine, which together with 4-hydroxyphenylacetaldehyde, an aldehyde derived from ty... Present in: 105 eukaryotes / 0 prokaryotes	77	90	105	13	2.3377	0.0115	31
00960 - Tropane, piperidine and pyridine alkaloid biosynthesis Metabolism; Biosynthesis of other secondary metabolites UMBBD: caf, caf2 ... Present in: 105 eukaryotes / 0 prokaryotes	16	10	105	7	1.2500	0.0003	3
00965 - Betalain biosynthesis Metabolism; Biosynthesis of other secondary metabolites Betalains are water-soluble nitrogen-containing pigments that are present in plants belonging to the order Caryophyllales (such as cactus and amaranth families) and in higher fungi. They contain betalamic acid as the chromophore and are classified into two types: betacyanins and betaxanthins. Betacyanins contain a cyclo-DOPA residue and exhibit red/violet coloration, while betaxanthins contain different amino acids or amino side chains and exhibit a yellow/orange coloration. The condensation of ... Present in: 92 eukaryotes / 0 prokaryotes	4	4	92	4	2.0000	0.0833	2
00970 - Aminoacyl-tRNA biosynthesis Aminoacyl-tRNA biosynthesis Genetic Information Processing; Translation... Present in: 531 eukaryotes / 5581 prokaryotes	12	7	6112	5	1.1667	0.0008	4
00980 - Metabolism of xenobiotics by cytochrome P450 Metabolism; Xenobiotics biodegradation and metabolism Cortisone reductase deficiency, Primary congenital glaucoma ... Present in: 248 eukaryotes / 0 prokaryotes	24	15	248	9	1.3000	0.0004	7
00981 - Insect hormone biosynthesis Metabolism; Metabolism of terpenoids and polyketides ... Present in: 71 eukaryotes / 0 prokaryotes	7	8	71	3	2.2857	0.0857	1
00982 - Drug metabolism - cytochrome P450 Metabolism; Xenobiotics biodegradation and metabolism Poor drug metabolism, Coumarin resistance, Trimethylaminuria ... Present in: 247 eukaryotes / 0 prokaryotes	17	57	247	4	1.4545	0.0020	4
00983 - Drug metabolism - other enzymes Metabolism; Xenobiotics biodegradation and metabolism Dihydropyrimidine dehydrogenase deficiency, Dihydropyrimidinase deficiency, Beta-ureidopropionase de ... Present in: 248 eukaryotes / 70 prokaryotes	34	43	318	9	2.2353	0.0050	15
00984 - Steroid degradation Metabolism; Xenobiotics biodegradation and metabolism GO: 0006707 ... Present in: 0 eukaryotes / 368 prokaryotes	14	13	368	3	1.8571	0.0069	9
00998 - Biosynthesis of secondary metabolites - other antibiotics Metabolism; Biosynthesis of other secondary metabolites Cycloserine biosynthesis, arginine/serine => cycloserine [PATH:map00998], Bacilysin biosynthesis, pr ... Present in: 90 eukaryotes / 342 prokaryotes	43	30	432	13	1.3810	0.0011	18
00999 - Biosynthesis of secondary metabolites - unclassified Metabolism; Biosynthesis of other secondary metabolites Staphyloferrin B biosynthesis, L-serine => staphyloferrin B [PATH:map00999], Staphyloferrin A biosyn ... Present in: 91 eukaryotes / 531 prokaryotes	38	30	622	9	1.5263	0.0014	19
01053 - Biosynthesis of siderophore group nonribosomal peptides Metabolism; Metabolism of terpenoids and polyketides ... Present in: 11 eukaryotes / 1128 prokaryotes	5	4	1139	2	1.6000	0.0667	4
01055 - Biosynthesis of vancomycin group antibiotics Metabolism; Metabolism of terpenoids and polyketides D00212, Vancomycin (USP) ... Present in: 0 eukaryotes / 343 prokaryotes	8	6	343	3	1.5000	0.0119	1
01057 - Biosynthesis of type II polyketide products Metabolism; Metabolism of terpenoids and polyketides Dihydrokalafungin biosynthesis, octaketide => dihydrokalafungin [PATH:map01057], Tetracycline/oxytet ... Present in: 0 eukaryotes / 58 prokaryotes	33	25	58	8	1.4375	0.0014	18
01058 - Acridone alkaloid biosynthesis Metabolism; Biosynthesis of other secondary metabolites Acridone alkaloids are anthranillic acid-derived plant alkaloids found in Rutaceae (rue family). Compounds in this class have been tested for antitumor and antimicrobial activities.... Present in: 2 eukaryotes / 0 prokaryotes	3	2	2	3	1.3333	0.1667	2
01059 - Biosynthesis of enediyne antibiotics Metabolism; Metabolism of terpenoids and polyketides 9-membered enediyne core biosynthesis, malonyl-CoA => 3-hydroxyhexadeca-4,6,8,10,12,14-hexaenoyl-ACP Enediyne natural products are potent antitumor antibiotics produced by a variety of Actinomycetes. Enediyne has a unique structure consisting of three building blocks: aromatic, sugar and enediyne core. The enediyne core contains two acetylenic groups conjugated to a double bond in a 9- or 10-membered ring, and it is synthesized by an iterative type I polyketide synthase and other tailoring proteins [MD:M00824 M00825]. The 10-membered enediyne such as calicheamicin also contains an allylic trisu... Present in: 0 eukaryotes / 78 prokaryotes	6	4	78	3	1.3333	0.0333	2

KPV - KEGG Pathway Viewer by Igor Brandão

Loading..

Pathways List Use the list below to find informations about KEGG metabolic pathways. Click on the pathway name to access the network visualization.

40

132

6097

4

6.5000

0.1082

3

24

88

6016

4

7.1667

0.0800

0

46

167

6064

8

7.1739

0.0361

8

65

199

5540

11

6.1231

0.0502

13

64

182

6046

11

5.6250

0.0224

13

46

184

5733

5

6.1739

0.0383

2

46

111

4295

6

4.7391

0.0272

19

57

126

5762

13

3.2982

0.0835

16

34

88

523

9

3.4118

0.0538

1

44

115

5184

12

4.2273

0.0386

14

6

14

3802

2

4.6667

0.1000

0

KPV - KEGG Pathway Viewer
by Igor Brandão

Pathways List
Use the list below to find informations about KEGG metabolic pathways. Click on the pathway name to access the network visualization.