KPV - KEGG Pathway Viewer

Term	Meaning
Metabolic pathway	In biochemistry, a metabolic pathway is a linked series of chemical reactions occurring within a cell. The term network is sometimes defined to mean a graph in which attributes (e.g. names) are associated with the vertices and edges, and the subject that expresses and understands the real-world systems as a network is called network science.
Network/Graphs	In mathematics, graph theory is the study of graphs, which are mathematical structures used to model pairwise relations between objects.
Network visualization	Graph visualization is a way of representing structural information as diagrams of abstract graphs and networks. It has important applications in networking, bioinformatics, software engineering, database and web design, machine learning, and in visual interfaces for other technical domains.
Node	In mathematics, and more specifically in graph theory, a vertex (plural vertices) or node is the fundamental unit of which graphs are formed.
Edge	For an undirected graph, an unordered pair of nodes that specify a line joining these two nodes are said to form an edge. For a directed graph, the edge is an ordered pair of nodes. The terms "arc," "branch," "line," "link," and "1-simplex" are sometimes used instead of edge.
KEGG	KEGG: Kyoto Encyclopedia of Genes and Genomes is a Japanese database resource for understanding high-level functions and utilities of the biological system, such as the cell, the organism and the ecosystem, from molecular-level information, especially large-scale molecular datasets generated by genome sequencing and other high-throughput experimental technologies.
KEGG Pathway	KEGG PATHWAY is a collection of manually drawn pathway maps representing the knowledge on the molecular interaction, reaction and relation.
Pathway code	Each pathway map is identified by the combination of 2-4 letter prefix code and 5 digit number.
Articulation point	In a graph, a vertex is called an articulation point if removing it and all the edges associated with it results in the increase of the number of connected components in the graph.
Articulation point impact	The impact is defined as the number of vertices that get disconnected from the main (largest) surviving connected component after the removal of the articulation point node.
AP node	AP is the abbreviation for Articulation point.
HAP node	AP is the abbreviation for Hub and Articulation point.
HUB node	In network science, a hub is a node with a number of links that greatly exceeds the average.
Other nodes	In the context of this tool, other nodes represent nodes without classification.

00908 Zeatin biosynthesis
Metabolism; Metabolism of terpenoids and polyketides

Zeatin is a member of the cytokinin family, a class of phytohormones involved in various processes of growth and development in plants. Most abundant cytokinins are adenine-type, where the N6 position of adenine is substituted with an isoprenoid, such as in zeatin, or an aromatic side chain, such as in kinetin. Zeatin can be synthesized in two different pathways: the tRNA pathway and the AMP pathway. In the tRNA pathway zeatin is a recycled product of isopentenylated tRNAs. In the AMP pathway zeatin is synthesized from an isopentenyl donor, dimethylallyl diphosphate (DMAPP), and AMP, ADP, or ATP by isopentenyltransferases. After synthesis cytokinins can be glucosylated.

Nodes	Edges
4	3

Articulation point with highest impact	Disconnected nodes when remove it
ec:1.3.1.69	1

Global metrics
4	1.5000	0.0000

Nodes classification
1	1	1	3

Total organisms
91

Eukaryotes	Prokaryotes
91	0

Animals	Plants	Fungi	Protists	Bacteria	Archaea
0	91	0	0	0	0

list(REFERENCE = "PMID:14726522", AUTHORS = "Kasahara H, Takei K, Ueda N, Hishiyama S, Yamaya T, Kamiya Y, Yamaguchi S, Sakakibara H.", TITLE = "Distinct isoprenoid origins of cis- and trans-zeatin biosyntheses in Arabidopsis.", JOURNAL = c("J Biol Chem 279:14049-54 (2004)", "DOI:10.1074/jbc.M314195200")), list(REFERENCE = "PMID:11313355", AUTHORS = "Takei K, Sakakibara H, Sugiyama T.", TITLE = "Identification of genes encoding adenylate isopentenyltransferase, a cytokinin biosynthesis enzyme, in Arabidopsis thaliana.", JOURNAL = c("J Biol Chem 276:26405-10 (2001)", "DOI:10.1074/jbc.M102130200")), list(REFERENCE = "PMID:11479373", AUTHORS = "Kakimoto T.", TITLE = "Identification of plant cytokinin biosynthetic enzymes as dimethylallyl diphosphate:ATP/ADP isopentenyltransferases.", JOURNAL = c("Plant Cell Physiol 42:677-85 (2001)", "DOI:10.1093/pcp/pce112")), list(REFERENCE = "PMID:15280363", AUTHORS = "Takei K, Yamaya T, Sakakibara H.", TITLE = "Arabidopsis CYP735A1 and CYP735A2 encode cytokinin hydroxylases that catalyze the biosynthesis of trans-Zeatin.", JOURNAL = c("J Biol Chem 279:41866-72 (2004)", "DOI:10.1074/jbc.M406337200")), list(REFERENCE = "PMID:15342621", AUTHORS = "Hou B, Lim EK, Higgins GS, Bowles DJ.", TITLE = "N-glucosylation of cytokinins by glycosyltransferases of Arabidopsis thaliana.", JOURNAL = c("J Biol Chem 279:47822-32 (2004)", "DOI:10.1074/jbc.M409569200")), list(REFERENCE = "PMID:9874810", AUTHORS = "Martin RC, Mok MC, Mok DW", TITLE = "Isolation of a cytokinin gene, ZOG1, encoding zeatin O-glucosyltransferase from Phaseolus lunatus.", JOURNAL = c("Proc Natl Acad Sci U S A 96:284-9 (1999)", "DOI:10.1073/pnas.96.1.284")), list(REFERENCE = "PMID:10364407", AUTHORS = "Martin RC, Mok MC, Mok DW", TITLE = "A gene encoding the cytokinin enzyme zeatin O-xylosyltransferase of Phaseolus vulgaris.", JOURNAL = c("Plant Physiol 120:553-8 (1999)", "DOI:10.1104/pp.120.2.553")), list(REFERENCE = "PMID:12644686", AUTHORS = "Veach YK, Martin RC, Mok DW, Malbeck J, Vankova R, Mok MC", TITLE = "O-glucosylation of cis-zeatin in maize. Characterization of genes, enzymes, and endogenous cytokinins.", JOURNAL = c("Plant Physiol 131:1374-80 (2003)", "DOI:10.1104/pp.017210")), list(REFERENCE = "PMID:14555694", AUTHORS = "Werner T, Motyka V, Laucou V, Smets R, Van Onckelen H, Schmulling T", TITLE = "Cytokinin-deficient transgenic Arabidopsis plants show multiple developmental alterations indicating opposite functions of cytokinins in the regulation of shoot and root meristem activity.", JOURNAL = c("Plant Cell 15:2532-50 (2003)", "DOI:10.1105/tpc.014928")), list(REFERENCE = "PMID:17062755", AUTHORS = "Miyawaki K, Tarkowski P, Matsumoto-Kitano M, Kato T, Sato S, Tarkowska D, Tabata S, Sandberg G, Kakimoto T", TITLE = "Roles of Arabidopsis ATP/ADP isopentenyltransferases and tRNA isopentenyltransferases in cytokinin biosynthesis.", JOURNAL = c("Proc Natl Acad Sci U S A 103:16598-603 (2006)", "DOI:10.1073/pnas.0603522103"))

Nodes classification
Articulation points (AP)	Hub & AP	Hubs	Other nodes
1	1	1	3

KPV - KEGG Pathway Viewer
by Igor Brandão

Loading..

00908 Zeatin biosynthesis
Metabolism; Metabolism of terpenoids and polyketides

4
NODES

3
EDGES

91
ORGANISMS

4
COMMUNITIES

1.5000
AVG. DEGREE

0.0000
AVG. BETWEENNESS

1
ARTICULATION POINTS

3
OTHER NODES

Filters

Pathway Viewer

4

3

ec:1.3.1.69

1

4

1.5000

0.0000

1

1

1

3

91

91

0

0

91

0

0

0

0

Global metrics
Communities	Avg. degree	Avg. betweenness
4	1.5000	0.0000

KPV - KEGG Pathway Viewer by Igor Brandão

Loading..

00908 Zeatin biosynthesis Metabolism; Metabolism of terpenoids and polyketides

4 NODES

3 EDGES

91 ORGANISMS

4 COMMUNITIES

1.5000 AVG. DEGREE

0.0000 AVG. BETWEENNESS

1 ARTICULATION POINTS

3 OTHER NODES