list(REFERENCE = "PMID:20336235", AUTHORS = "Liang ZX", TITLE = "Complexity and simplicity in the biosynthesis of enediyne natural products.", JOURNAL = c("Nat Prod Rep 27:499-528 (2010)", "DOI:10.1039/b908165h")), list(REFERENCE = "PMID:18397168", AUTHORS = "Van Lanen SG, Shen B", TITLE = "Biosynthesis of enediyne antitumor antibiotics.", JOURNAL = c("Curr Top Med Chem 8:448-59 (2008)", "DOI:10.2174/156802608783955656")), list(REFERENCE = "PMID:12183628", AUTHORS = "Liu W, Christenson SD, Standage S, Shen B", TITLE = "Biosynthesis of the enediyne antitumor antibiotic C-1027.", JOURNAL = c("Science 297:1170-3 (2002)", "DOI:10.1126/science.1072110")), list(REFERENCE = "PMID:12183629", AUTHORS = "Ahlert J, Shepard E, Lomovskaya N, Zazopoulos E, Staffa A, Bachmann BO, Huang K, Fonstein L, Czisny A, Whitwam RE, Farnet CM, Thorson JS", TITLE = "The calicheamicin gene cluster and its iterative type I enediyne PKS.", JOURNAL = c("Science 297:1173-6 (2002)", "DOI:10.1126/science.1072105")), list(REFERENCE = "PMID:17918933", AUTHORS = "Van Lanen SG, Oh TJ, Liu W, Wendt-Pienkowski E, Shen B", TITLE = "Characterization of the maduropeptin biosynthetic gene cluster from Actinomadura madurae ATCC 39144 supporting a unifying paradigm for enediyne biosynthesis.", JOURNAL = c("J Am Chem Soc 129:13082-94 (2007)", "DOI:10.1021/ja073275o")), list(REFERENCE = "PMID:15797213", AUTHORS = "Liu W, Nonaka K, Nie L, Zhang J, Christenson SD, Bae J, Van Lanen SG, Zazopoulos E, Farnet CM, Yang CF, Shen B", TITLE = "The neocarzinostatin biosynthetic gene cluster from Streptomyces carzinostaticus ATCC 15944 involving two iterative type I polyketide synthases.", JOURNAL = c("Chem Biol 12:293-302 (2005)", "DOI:10.1016/j.chembiol.2004.12.013")), list(REFERENCE = "PMID:23360970", AUTHORS = "Lohman JR, Huang SX, Horsman GP, Dilfer PE, Huang T, Chen Y, Wendt-Pienkowski E, Shen B", TITLE = "Cloning and sequencing of the kedarcidin biosynthetic gene cluster from Streptoalloteichus sp. ATCC 53650 revealing new insights into biosynthesis of the enediyne family of antitumor antibiotics.", JOURNAL = c("Mol Biosyst 9:478-91 (2013)", "DOI:10.1039/c3mb25523a")), list(REFERENCE = "PMID:19362637", AUTHORS = "Horsman GP, Van Lanen SG, Shen B", TITLE = "Iterative type I polyketide synthases for enediyne core biosynthesis.", JOURNAL = c("Methods Enzymol 459:97-112 (2009)", "DOI:10.1016/S0076-6879(09)04605-9")), list(REFERENCE = "PMID:20024241", AUTHORS = "Sun H, Kong R, Zhu D, Lu M, Ji Q, Liew CW, Lescar J, Zhong G, Liang ZX", TITLE = "Products of the iterative polyketide synthases in 9- and 10-membered enediyne biosynthesis.", JOURNAL = c("Chem Commun (Camb) 7399-401 (2009)", "DOI:10.1039/b916751j")), list(REFERENCE = "PMID:18223152", AUTHORS = "Zhang J, Van Lanen SG, Ju J, Liu W, Dorrestein PC, Li W, Kelleher NL, Shen B", TITLE = "A phosphopantetheinylating polyketide synthase producing a linear polyene to initiate enediyne antitumor antibiotic biosynthesis.", JOURNAL = c("Proc Natl Acad Sci U S A 105:1460-5 (2008)", "DOI:10.1073/pnas.0711625105")), list(REFERENCE = "PMID:19689130", AUTHORS = "Belecki K, Crawford JM, Townsend CA", TITLE = "Production of octaketide polyenes by the calicheamicin polyketide synthase CalE8: implications for the biosynthesis of enediyne core structures.", JOURNAL = c("J Am Chem Soc 131:12564-6 (2009)", "DOI:10.1021/ja904391r")), list(REFERENCE = "PMID:19357082", AUTHORS = "Kotaka M, Kong R, Qureshi I, Ho QS, Sun H, Liew CW, Goh LP, Cheung P, Mu Y, Lescar J, Liang ZX", TITLE = "Structure and catalytic mechanism of the thioesterase CalE7 in enediyne biosynthesis.", JOURNAL = c("J Biol Chem 284:15739-49 (2009)", "DOI:10.1074/jbc.M809669200")), list(REFERENCE = "PMID:24041368", AUTHORS = "Belecki K, Townsend CA", TITLE = "Biochemical determination of enzyme-bound metabolites: preferential accumulation of a programmed octaketide on the enediyne polyketide synthase CalE8.", JOURNAL = c("J Am Chem Soc 135:14339-48 (2013)", "DOI:10.1021/ja406697t")), list(REFERENCE = "PMID:20534556", AUTHORS = "Horsman GP, Chen Y, Thorson JS, Shen B", TITLE = "Polyketide synthase chemistry does not direct biosynthetic divergence between 9- and 10-membered enediynes.", JOURNAL = c("Proc Natl Acad Sci U S A 107:11331-5 (2010)", "DOI:10.1073/pnas.1003442107")), list(REFERENCE = "PMID:25278375", AUTHORS = "Chen X, Ji R, Jiang X, Yang R, Liu F, Xin Y", TITLE = "Iterative type I polyketide synthases involved in enediyne natural product biosynthesis.", JOURNAL = c("IUBMB Life 66:587-95 (2014)", "DOI:10.1002/iub.1316")), list(REFERENCE = "PMID:19856960", AUTHORS = "Lin S, Horsman GP, Chen Y, Li W, Shen B", TITLE = "Characterization of the SgcF epoxide hydrolase supporting an (R)-vicinal diol intermediate for enediyne antitumor antibiotic C-1027 biosynthesis.", JOURNAL = c("J Am Chem Soc 131:16410-7 (2009)", "DOI:10.1021/ja901242s")), list(REFERENCE = "PMID:23844627", AUTHORS = "Horsman GP, Lechner A, Ohnishi Y, Moore BS, Shen B", TITLE = "Predictive model for epoxide hydrolase-generated stereochemistry in the biosynthesis of nine-membered enediyne antitumor antibiotics.", JOURNAL = c("Biochemistry 52:5217-24 (2013)", "DOI:10.1021/bi400572a")), list(REFERENCE = "PMID:20704329", AUTHORS = "Lin S, Horsman GP, Shen B", TITLE = "Characterization of the epoxide hydrolase NcsF2 from the neocarzinostatin biosynthetic gene cluster.", JOURNAL = c("Org Lett 12:3816-9 (2010)", "DOI:10.1021/ol101473t")), list(REFERENCE = "PMID:18182490", AUTHORS = "Van Lanen SG, Lin S, Shen B", TITLE = "Biosynthesis of the enediyne antitumor antibiotic C-1027 involves a new branching point in chorismate metabolism.", JOURNAL = c("Proc Natl Acad Sci U S A 105:494-9 (2008)", "DOI:10.1073/pnas.0708750105")), list(REFERENCE = "PMID:14580219", AUTHORS = "Christenson SD, Wu W, Spies MA, Shen B, Toney MD", TITLE = "Kinetic analysis of the 4-methylideneimidazole-5-one-containing tyrosine aminomutase in enediyne antitumor antibiotic C-1027 biosynthesis.", JOURNAL = c("Biochemistry 42:12708-18 (2003)", "DOI:10.1021/bi035223r")), list(REFERENCE = "PMID:16887797", AUTHORS = "Van Lanen SG, Lin S, Dorrestein PC, Kelleher NL, Shen B", TITLE = "Substrate specificity of the adenylation enzyme SgcC1 involved in the biosynthesis of the enediyne antitumor antibiotic C-1027.", JOURNAL = c("J Biol Chem 281:29633-40 (2006)", "DOI:10.1074/jbc.M605887200")), list(REFERENCE = "PMID:16104723", AUTHORS = "Van Lanen SG, Dorrestein PC, Christenson SD, Liu W, Ju J, Kelleher NL, Shen B", TITLE = "Biosynthesis of the beta-amino acid moiety of the enediyne antitumor antibiotic C-1027 featuring beta-amino acyl-S-carrier protein intermediates.", JOURNAL = c("J Am Chem Soc 127:11594-5 (2005)", "DOI:10.1021/ja052871k")), list(REFERENCE = "PMID:18426211", AUTHORS = "Lin S, Van Lanen SG, Shen B", TITLE = "Characterization of the two-component, FAD-dependent monooxygenase SgcC that requires carrier protein-tethered substrates for the biosynthesis of the enediyne antitumor antibiotic C-1027.", JOURNAL = c("J Am Chem Soc 130:6616-23 (2008)", "DOI:10.1021/ja710601d")), list(REFERENCE = "PMID:19817865", AUTHORS = "Van Lanen SG, Lin S, Horsman GP, Shen B", TITLE = "Characterization of SgcE6, the flavin reductase component supporting FAD-dependent halogenation and hydroxylation in the biosynthesis of the enediyne antitumor antibiotic C-1027.", JOURNAL = c("FEMS Microbiol Lett 300:237-41 (2009)", "DOI:10.1111/j.1574-6968.2009.01802.x")), list(REFERENCE = "PMID:23034235", AUTHORS = "Lohman JR, Shen B", TITLE = "4-methylideneimidazole-5-one-containing aminomutases in enediyne biosynthesis.", JOURNAL = c("Methods Enzymol 516:299-319 (2012)", "DOI:10.1016/B978-0-12-394291-3.00007-1")), list(REFERENCE = "PMID:20718468", AUTHORS = "Ling J, Horsman GP, Huang SX, Luo Y, Lin S, Shen B", TITLE = "Enediyne antitumor antibiotic maduropeptin biosynthesis featuring a C-methyltransferase that acts on a CoA-tethered aromatic substrate.", JOURNAL = c("J Am Chem Soc 132:12534-6 (2010)", "DOI:10.1021/ja1050814")), list(REFERENCE = "PMID:23633564", AUTHORS = "Huang SX, Lohman JR, Huang T, Shen B", TITLE = "A new member of the 4-methylideneimidazole-5-one-containing aminomutase family from the enediyne kedarcidin biosynthetic pathway.", JOURNAL = c("Proc Natl Acad Sci U S A 110:8069-74 (2013)", "DOI:10.1073/pnas.1304733110")), list(REFERENCE = "PMID:18561189", AUTHORS = "McCoy JG, Johnson HD, Singh S, Bingman CA, Lei IK, Thorson JS, Phillips GN Jr", TITLE = "Structural characterization of CalO2: a putative orsellinic acid P450 oxidase in the calicheamicin biosynthetic pathway.", JOURNAL = c("Proteins 74:50-60 (2009)", "DOI:10.1002/prot.22131")), list(REFERENCE = "PMID:24978950", AUTHORS = "Singh S, Nandurkar NS, Thorson JS", TITLE = "Characterization of the calicheamicin orsellinate C2-O-methyltransferase CalO6.", JOURNAL = c("Chembiochem 15:1418-21 (2014)", "DOI:10.1002/cbic.201402119")), list(REFERENCE = "PMID:21358050", AUTHORS = "Chang A, Singh S, Bingman CA, Thorson JS, Phillips GN Jr", TITLE = "Structural characterization of CalO1: a putative orsellinic acid methyltransferase in the calicheamicin-biosynthetic pathway.", JOURNAL = c("Acta Crystallogr D Biol Crystallogr 67:197-203 (2011)", "DOI:10.1107/S090744491100360X"))
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